Not only is Mirtazapine effective in the treatment of depression, but it was more effective than amitriptyline, fluoxetine, paroxetine, and citalopram (R, R2).
Compared to SSRIs, patients using mirtazapine had a 74 percent greater likelihood of achieving remission during the first two weeks of therapy (R).
Depressed patients often retain more negative information about themselves.
Mirtazapine was shown to induce an effect in patients more likely to retain positive information regarding themselves (R).
In eight controlled trials of major depression, Mirtazapine improvement began in the first week of treatment and was significantly greater than placebo (R).