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The selectins are subtype IV C-type lectins defined the presence of the C-type lectin CRD, an epidermal growth factor-like domain and a variable number of complement regulatory protein-like repeat domains.

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Galectin-1 is expressed by antigen-stimulated T cells, activated B cells and by macrophages.

The action of galectin-1 in these systems is to stimulate apoptosis resulting in cell death.

P-selectin is constitutively stored in secretory granules of platelets and endothelial cells. IL-1 and TNF-α) these cells present P-selectin to the cell surface.

Through this mechanism, P-selectin is involved in mediating very early responses of leukocytes to inflammatory signals.

E-selectin is also synthesized by endothelial cells but is not constitutively present.